The place of maintenance antipsychotic treatment in schizophrenia has been questioned for two reasons. 2 The drugs have potentially serious adverse effects, and preliminary and uncontrolled evidence suggests that in some patients gradual dose reduction and, where feasible, discontinuation may be associated with better long term outcome. 3 However, stopping antipsychotic treatment is associated with very high rates of relapse, even after a single episode of psychosis. 4 Relapses may be associated with undue patient …
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