Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea

Amy P Abernethy. research fellow1 1 , David C Currow ( david. currowrgh. sa. gov. au ). professor 1 , Peter Frith. consultant 3 , Belinda S Fazekas. research manager 2 , Annie McHugh. research nurse 2 , Chuong Bui. consultant 4 1 Department of Palliative and Supportive Services, Division of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia 2 Southern Adelaide Palliative Services, Repatriation General Hospital, Daw Park, South Australia 5042, Australia 3 Respiratory Medicine Department, Repatriation General Hospital 4 Department of Nuclear Medicine, Nepean Hospital, Kingswood, New South Wales 2747, Australia Correspondence to: D C Currow

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

P S Burge. consultant chest physician ( burgepsaol. com ) a, P M A Calverley. professor of respiratory medicine b, P W Jones. professor of respiratory medicine c, S Spencer. research fellow c, J A Anderson. senior statistician d, T K Maslen. clinical project manager the ISOLDE study investigators d a Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS b Department of Medicine, University Hospital Aintree, Liverpool L9 7AL c Department of Physiological Medicine, St George's Hospital Medical School, London SW17 0RE d GlaxoWellcome Research and Development, Stockley Park West, Uxbridge, Middlesex UB11 1BT Correspondence to: P S Burge

Accepted 7 February 2000