Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

P S Burge. consultant chest physician ( burgepsaol. com ) a, P M A Calverley. professor of respiratory medicine b, P W Jones. professor of respiratory medicine c, S Spencer. research fellow c, J A Anderson. senior statistician d, T K Maslen. clinical project manager the ISOLDE study investigators d a Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS b Department of Medicine, University Hospital Aintree, Liverpool L9 7AL c Department of Physiological Medicine, St George's Hospital Medical School, London SW17 0RE d GlaxoWellcome Research and Development, Stockley Park West, Uxbridge, Middlesex UB11 1BT Correspondence to: P S Burge

Accepted 7 February 2000